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Title 

A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients

Authors 

U LeeC FrankenbergerJi Eun YunE BevilacquaC CaldasS F ChinO M RuedaJ ReinitzM R Rosner

Publisher 

Public Library of Science

Issue Date 

2013

Citation 

Plos One, vol. 8, no. 12, pp. e82125-e82125

Abstract 

Although triple negative breast cancers (TNBC) are the most aggressive subtype of breast cancer, they currently lack targeted therapies. Because this classification still includes a heterogeneous collection of tumors, new tools to classify TNBCs are urgently required in order to improve our prognostic capability for high risk patients and predict response to therapy. We previously defined a gene expression signature, RKIP Pathway Metastasis Signature (RPMS), based upon a metastasis-suppressive signaling pathway initiated by Raf Kinase Inhibitory Protein (RKIP). We have now generated a new BACH1 Pathway Metastasis gene signature (BPMS) that utilizes targets of the metastasis regulator BACH1. Specifically, we substituted experimentally validated target genes to generate a new BACH1 metagene, developed an approach to optimize patient tumor stratification, and reduced the number of signature genes to 30. The BPMS significantly and selectively stratified metastasis-free survival in basal-like and, in particular, TNBC patients. In addition, the BPMS further stratified patients identified as having a good or poor prognosis by other signatures including the Mammaprint® and Oncotype® clinical tests. The BPMS is thus complementary to existing signatures and is a prognostic tool for high risk ER-HER2- patients. We also demonstrate the potential clinical applicability of the BPMS as a single sample predictor. Together, these results reveal the potential of this pathway-based BPMS gene signature to identify high risk TNBC patients that can respond effectively to targeted therapy, and highlight BPMS genes as novel drug targets for therapeutic development.

ISSN 

1932-6203

Link 

http://dx.doi.org/10.1371/journal.pone.0082125

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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