상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Anti-inflammatory activities of methanol extract of Mastixia arboria C.B. Clarke as to mouse macrophage and paw edema

 

마스티시아 알보리아의 항염 효과

Authors 

Hui Seong KimOk-Kyoung KwonJi-Won ParkH G JeongSei-Ryang OhHyeong Kyu LeeT T BachD V HaiKyung Seop Ahn

Publisher 

Japan Society for Bioscience, Biotechnology and Agrochemistry

Issue Date 

2013

Citation 

Bioscience Biotechnology and Biochemistry, vol. 77, no. 12, pp. 2356-2361

Abstract 

The biological activity of Mastixia arborea (MA) relates to inflammation, but the underlying mechanisms are largely unknown. We confirmed the anti-inflammatory effects of a methanol extract of MA extract on lipopolysaccharide (LPS)-stimulated RAW264.7 mouse macrophage cells and carrageenan-induced mice paw edema. The MA extract significantly inhibited nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1β (IL-1β), and IL-6 production in LPS-stimulated RAW264.7 cells. In vitro expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was suppressed by the extract. The extract attenuated acute inflammatory responses in carrageenan-induced mice paw edema. A mechanism study indicated that translocation of the NF-κB (p65) subunit into the nucleus and phosphorylation of ERK and JNK were inhibited by the extract. These results indicate that the extract is an effective suppressor of the inflammatory response, blocking the phosphorylation of ERK and JNK and the translocation of NF-κB in macrophages, thereby producing an anti-inflammatory effect in vivo.

ISSN 

0916-8451

Link 

http://doi.org/10.1271/bbb.130429

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)