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Title 

Aralia cordata inhibits triacylglycerol biosynthesis in HepG2 cells

Authors 

Mun-Ock KimS H LeeJ H SeoI S KimAh Reum HanD O MoonSungchan ChoL CuiJ KimHyun Sun Lee

Publisher 

Mary Ann Liebert

Issue Date 

2013

Citation 

Journal of Medicinal Food, vol. 16, no. 12, pp. 1108-1114

Keywords 

Aralia cordataEnt-pimara-8(14),15-dien-19-oic acidGlycerol-3-phosphate acyltransferaseLysophophatidic acidTriacylglycerol

Abstract 

Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first committed step in triacylglycerol (TAG) and phospholipid biosynthesis, and has been considered as one of the drug targets for treating hepatic steatosis, insulin resistance, and other metabolic disorders. The aim of this study was to investigate the GPAT inhibitors from natural products and to evaluate their effects. The methanol extract of Aralia cordata roots showed a strong inhibitory effect on the human GPAT1 activity. A further bioactivity-guided approach led to the isolation of ent-pimara-8(14),15-dien-19-oic acid, (PA), one of the major compounds of A. cordata, which suppressed the GPAT1 activity with IC 50 value of 60.5 μM. PA markedly reduced de novo lysophosphatidic acid synthesis through inhibition of GPAT activity and therefore significantly decreased synthesis of TAG in the HepG2 cells. These results suggest that PA as well as A. cordata root extract could be beneficial in controlling lipid metabolism.

ISSN 

1096-620X

Link 

http://dx.doi.org/10.1089/jmf.2012.2636

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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