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Title 

Comparative proteomic analyses of synovial fluids and serums from rheumatoid arthritis patients

Authors 

R NohSung Goo ParkJ H JuSeung-Wook ChiSunhong KimC K LeeJeong Hoon KimByoung Chul Park

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2014

Citation 

Journal of Microbiology and Biotechnology, vol. 24, no. 1, pp. 119-126

Keywords 

Proteomic analysesRheumatoid arthritisSerumSynovial fluid

Abstract 

Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disorder that primarily affects the flexible joints and may also affect a number of tissues and organs. The progression of RA involves an inflammatory response of the capsule around the joint, swelling of synovial cells with excess synovial fluid (SF), and the development of fibrous tissue in the synovium. Since the progressive pathology of the disease often leads to the irreversible destruction of articular cartilage and ankylosis of the joint, early diagnosis of RA is essential. Thus, we undertook a comparative proteomic approach to investigate novel biomarkers for early diagnosis using SFs and serums from RA patients. As a result, we identified 32 differentially expressed spots in SFs and 34 spots in serums. The differential expression of the STEAP4 and ZNF 658 proteins were validated using immunoblotting of the SFs and serums, respectively. These data suggest that differentially expressed proteins in SFs and serums could be used as RA-specific biomarkers for the diagnosis and monitoring of RA. Furthermore, these findings advance our understanding of the molecular etiopathogenesis of RA.

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.1307.07046

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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