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Title 

Metabolite changes signal genetic regulatory mechanisms for robust cell behavior

Authors 

Sang Jun LeeA TrostelS Adhya

Publisher 

American Society for Microbiology

Issue Date 

2014

Citation 

mBio, vol. 5, no. 1, pp. e00972-e00972

Abstract 

Exploiting mechanisms of utilizing the sugar D-galactose in Escherichia coli as a model system, we explored the consequences of accumulation of critical intermediates of the D-galactose metabolic pathways by monitoring cell growth, metabolites, and transcript profiles. These studies revealed both metabolic network changes far from the D-galactose pathway and changes in the global gene regulatory network. The concentration change of a critical intermediate disturbs the equilibrium state, generating a ripple effect through several metabolic pathways that ends up signaling up- or downregulation of specific sets of genes in a programmed manner to cope with the imbalance. Such long-range effects on metabolites and genetic regulatory mechanisms not only may be a common feature in bacteria but very likely operate during cellular development and differentiation in higher organisms as well as in disease cells, like cancer cells

ISSN 

2150-7511

Link 

http://dx.doi.org/10.1128/mBio.00972-13

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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