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Title 

Optimized production of 2,3-butanediol by a lactate dehydrogenase-deficient mutant of Klebsiella pneumoniae

 

Lactate dehydrogenase 결손 Klebsiella pneumoniae를 사용한 2,3-Butanediol 최적 생산

Authors 

S B LeeBaek Rock OhJang Min ParkA YuSun-Yeon HeoWon-Kyung HongJeong-Woo SeoChul Ho Kim

Publisher 

Springer Verlag (Germany)

Issue Date 

2013

Citation 

Biotechnology and Bioprocess Engineering, vol. 18, no. 0, pp. 1210-1215

Keywords 

2,3-butanediolKlebsiella pneumoniaelactate dehydrogenasedeficient mutantresponse surface methodologysugarcane molasses

Abstract 

To obtain high-yield production of 2,3-butanediol (2,3-BD) from glucose, we optimized the culture conditions for a lactate dehydrogenase-deficient mutant (ΔldhA) of Klebsiella pneumoniae using response surface methodology. 2,3-BD production was successfully improved by optimizing pH (5.6), aeration (3.50 vvm) and concentration of corn steep liquor (45.0 mL/L) as a nitrogen source, resulting in a maximum level of 2,3-BD production of 148.8 g/L and productivity of 2.48 g/L/h. 2,3-BD was also obtained with high concentration (76.24 g/L) and productivity (2.31 g/L/h) from the K. pneumoniae mutant strain using sugarcane molasses as a carbon source.

ISSN 

1226-8372

Link 

http://dx.doi.org/10.1007/s12257-013-0396-z

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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