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Title 

Anti-inflammatory activity of a methanol extract from Ardisia tinctoria on mouse macrophages and paw edema

 

알디시아 팅크토리아의 항염효과

Authors 

Hui Seong KimJi-Won ParkOk-Kyoung KwonJ H KimSei-Ryang OhHyeong Kyu LeeT T BachB H QuangKyung Seop Ahn

Publisher 

Spandidos Publications

Issue Date 

2014

Citation 

Molecular Medicine Reports, vol. 9, no. 0, pp. 1388-1394

Keywords 

Ardisia tinctoriaInflammationMAPKNF-κBNitric oxid

Abstract 

Ardisia tinctoria (AT) is a plant of the Myrsinaceae family. No studies on its anti-inflammatory effects have yet been reported. This study investigated the anti-inflammatory activity of AT. A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to significantly reduced levels of nitric oxide (NO) and prostaglandin E2 ( PGE2) and of two proteins regulated by these, interleukin-1β (IL-1β) and IL-6, in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The thickness of paw edema induced in vivo in mice by carrageenan administration was effectively reduced by the AT extract. Translocation of the nuclear factor-kappa; B (NF-kappa; B) subunit 65 (p65) into the nucleus and phosphorylation of mitogen-activated protein kinase kinase (MEK) and extracellular signal-related kinase (ERK) were inhibited by the AT extract. Our results indicated that a methanol extract of AT downregulates the inflammatory response by blocking phosphorylation of MEK and ERK and activation of NF-kappa; B. To the best of our knowledge, this is the first study of anti-inflammatory effects of an AT extract, and demonstrates its potential in the treatment of inflammatory diseases.

ISSN 

1791-2997

Link 

http://dx.doi.org/10.3892/mmr.2014.1941

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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