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Title 

Pitx3 deficient mice as a genetic animal model of co-morbid depressive disorder and parkinsonism

Authors 

Kyoung Shim KimY M KangYoung KangTae Shin ParkHye Yeon ParkY J KimBaek Soo HanC H KimChul Ho LeeP A ArdayfioP L HanBong Hyun ChungK S Kim

Publisher 

Elsevier

Issue Date 

2014

Citation 

Brain Research, vol. 1552, no. 0, pp. 72-81

Keywords 

c-FosDepressionParkinson's diseaseStress

Abstract 

Approximately 40-50% of all patients with Parkinson's disease (PD) show symptoms and signs of depressive disorders, for which neither pathogenic understanding nor rational treatment are available. Using Pit3x-deficient mice, a model for selective nigrostriatal dopaminergic neurodegeneration, we tested depression-related behaviors and acute stress responses to better understand how a nigrostriatal dopaminergic deficit increases the prevalence of depressive disorders in PD patients. Pitx3-deficient mice showed decreased sucrose consumption and preference in the two-bottle free-choice test of anhedonia. Acute restraint stress increased c-Fos (known as a neuronal activity marker) expression levels in various brain regions, including the prefrontal cortex, striatum, nucleus accumbens, and paraventricular nucleus of the hypothalamus (PVN), in both Pitx3+/+ and -/- mice. However, the stress-induced increases in c-Fos levels in the cortex, dorsal striatum, and PVN were significantly greater in Pitx3-/- than +/+ mice, suggesting that signs of depressive disorders in parkinsonism are related to altered stress vulnerability. Based on these results, we propose that Pitx3-/- mice may serve as a useful genetic animal model for co-morbid depressive disorder and parkinsonism.

ISSN 

0006-8993

Link 

http://dx.doi.org/10.1016/j.brainres.2014.01.023

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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