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Title 

Anti-inflammatory compounds from the aerial parts of aceriphyllum rossii

Authors 

T T T TrangT D CuongT M HungJ A KimJ H LeeM H WooJ S ChoiHyeong Kyu LeeB S Min

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2014

Citation 

Chemical & Pharmaceutical Bulletin, vol. 62, no. 2, pp. 185-190

Keywords 

Aceriphyllum rossiiAnti-inflammatory activityMegastigmaneSaxifragaceae

Abstract 

A new megastigmane glycoside, galloyl linarionoside A (1), together with 13 known compounds (2-14) were isolated from the aerial parts of Aceriphyllum rossii ENGLER. (Saxifragaceae). The chemical structures of the isolated compounds were established mainly by using nuclear magnetic resonance spectra, mass spectrometry, and modified Mosher's method. Among the isolates, compounds 4, 5, 6 and 7 showed potent inhibitory activity against the lipopolysaccharide- induced nitric oxide production in RAW264.7 macrophage cells with IC50 values of 12.5, 9.5, 10.5 and 9.3 μM, respectively. The anti-inflammatory effect of compound 7 was accompanied by dose-dependent decreases in the production of inducible nitric oxide synthase and cyclooxygenase- 2 proteins not in the inhibitor kappa B (IκB)-dependent nuclear factor-kappa B activation.

ISSN 

0009-2363

Link 

http://dx.doi.org/10.1248/cpb.c13-00664

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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