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Title 

Isolation and genetic characterization of naturally NS-truncated H3N8 equine influenza virus in South Korea

Authors 

Woon Sung NaB KangH I KimMin Ki HongS J ParkH Y JeoungD J AnH MoonJ K KimDae Sub Song

Publisher 

Cambridge University Press

Issue Date 

2014

Citation 

Epidemiology and Infection, vol. 142, no. 4, pp. 759-766

Keywords 

Equine influenza virusH3N8NS1 truncationSouth Korea

Abstract 

Equine influenza virus (EIV) causes a highly contagious respiratory disease in equids, with confirmed outbreaks in Europe, America, North Africa, and Asia. Although China, Mongolia, and Japan have reported equine influenza outbreaks, Korea has not. Since 2011, we have conducted a routine surveillance programme to detect EIV at domestic stud farms, and isolated H3N8 EIV from horses showing respiratory disease symptoms. Here, we characterized the genetic and biological properties of this novel Korean H3N8 EIV isolate. This H3N8 EIV isolate belongs to the Florida sublineage clade 1 of the American H3N8 EIV lineage, and surprisingly, possessed a non-structural protein (NS) gene segment, where 23 bases of the NS1-encoding region were naturally truncated. Our preliminary biological data indicated that this truncation did not affect virus replication; its effect on biological and immunological properties of the virus will require further study.

ISSN 

0950-2688

Link 

http://dx.doi.org/10.1017/S095026881300143X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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