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Title 

Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057

Authors 

Mijin OhJae-Hyuk JangS J ChooSun Ok KimJong Won KimSung-Kyun KoNak Kyun SoungJung-Sook LeeChang-Jin KimH OhYoung-Soo HongM UekiH HirotaH OsadaBo Yeon KimJong Seog Ahn

Publisher 

Elsevier

Issue Date 

2014

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 24, no. 7, pp. 1802-1804

Keywords 

BoseongazepinesCytotoxicityPyrrolobenzodiazepineStreptomyces

Abstract 

Three new pyrrolobenzodiazepine derivatives, boseongazepines A-C (1-3), were isolated from a culture broth of Streptomyces sp. 11A057, together with the known compound usabamycin B (4). The structures of 1-4 were determined through the analysis of spectroscopic data including extensive 1D-, 2D-NMR, and MS techniques. Cell growth inhibition effects of these compounds were evaluated against Jurkat, K-562, HL-60, and HepG2 cell lines.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2014.02.022

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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