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Title 

Perspectives on the therapeutic potential of short-chain fatty acid receptors

 

단쇄지방산 수용체의 치료제 잠재성

Authors 

Sunhong KimJeong Hoon KimBi Oh ParkY S Kwak

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2014

Citation 

BMB Reports, vol. 47, no. 3, pp. 173-178

Keywords 

GPR41GPR43InflammationObesitySCFA

Abstract 

There is rapidly growing interest in the human microbiome because of its implication in metabolic disorders and inflammatory diseases. Consequently, understanding the biology of short chain fatty acids and their receptors has become very important for identifying novel therapeutic avenues. GPR41 and GPR43 have been recognized as the cognate receptors for SCFAs and their roles in metabolism and inflammation have drawn much attention in recent years. GPR43 is highly expressed on immune cells and has been suggested to play a role in inflammatory diseases such as inflammatory bowel disease. Both GPR41 and GPR43 have been implicated in diabetes and obesity via the regulation of adipose tissue and gastrointestinal hormones. So far, many studies have provided contradictory results, and therefore further research is required to validate these receptors as drug targets. We will also discuss the synthetic modulators of GPR41 and GPR43 that are critical to understanding the functions of these receptors.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2014.47.3.272

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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