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Title 

Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin

Authors 

M J KangG S KoD G OhJ S KimK NohW KangWoon Kee YoonHyoung-Chin KimH G JeongT C Jeong

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2014

Citation 

Archives of Pharmacal Research, vol. 37, no. 3, pp. 371-373

Keywords 

BaicalinIntestinal bacteriaKineticsMetabolismRat

Abstract 

Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were investigated in normal and antibiotic-pretreated rats following p.o. administration of 100 mg/kg baicalin by using liquid chromatography/ion trap mass spectrometry. When rats were pretreated orally with cefadroxil, oxytetracycline and erythromycin for 3 days to control the number of intestinal bacteria, the pharmacokinetic parameters of oral baicalin were significantly affected by antibiotics: Cmax, T1/2(β), K el and AUC values were significantly changed compared to those in normal rats. These results indicate that intestinal microbiota might play a key role in the oral pharmacokinetics of baicalin.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-013-0179-2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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