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Title 

Carthami Flos suppresses neutrophilic lung inflammation in mice, for which nuclear factor-erythroid 2-related factor-1 is required

 

카타미플로스의 호중구성 폐염증 완화 효과

Authors 

J KimJ WooJ H LyuHyuk Hwan SongH S JeongK T HaJ Y ChoiC W HanKyung Seop AhnSei-Ryang OhR T SadikotK H KimM Joo

Publisher 

Elsevier

Issue Date 

2014

Citation 

Phytomedicine, vol. 21, no. 4, pp. 470-478

Keywords 

Carthami FlosLipopolysaccharideNeutrophilic lung inflammationNuclear factor-erythroid 2-related factor-1Therapeutic effect

Abstract 

Carthami Flos (CF) is used in traditional Asian medicine to treat blood stagnation and its associated diseases in patients. While the underlying mechanism for this effect remains unknown, CF has been reported to activate Nrf2, a transcription factor that is critical in protecting from various inflammatory lung diseases including acute lung injury (ALI). Here, we examined whether CF has a therapeutic effect on lung inflammation and assessed the impact of Nrf2 on the effect of CF using an ALI mouse model. Treatment of bone marrow derived macrophages with standardized aqueous extract of CF (AECF) activated Nrf2, resulting in the expression of Nrf2 dependent genes including GCLC, NQO-1 and HO-1. While intranasal LPS treatment of wild type mice resulted in neutrophilic infiltration and a concomitant expression of pro-inflammatory cytokine genes in the lung, the hallmarks of ALI, an intratracheal spraying of AECF to the lung 2 h after LPS treatment suppressed the inflammatory response. By contrast, similar treatment in nrf2-/- mice with AECF failed to attenuate the inflammatory response. Thus, our results show that AECF attenuated neutrophilic lung inflammation in mice, which required Nrf2. Since AECF administration abrogates lung inflammation after LPS treatment, we propose CF as a potential therapeutics in the management of ALI.

ISSN 

0944-7113

Link 

http://dx.doi.org/10.1016/j.phymed.2013.10.005

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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