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Title 

Hepatoprotective effect of aged black garlic extract in rodents

Authors 

Jung Hyu ShinChang Woo LeeSoo Jin OhJi Eun YunMoo Rim KangS B HanH ParkJ C JungY H ChungJong Soon Kang

Publisher 

The Korean Society of Toxicology

Issue Date 

2014

Citation 

Toxicological Research, vol. 30, no. 1, pp. 49-54

Keywords 

Aged black garlicCarbon tetrachlorideD-galactosamineLiver injuryNon-alcoholic fatty liver disease

Abstract 

In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.

ISSN 

1976-8257

Link 

http://dx.doi.org/10.5487/TR.2014.30.1.049

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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