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Title 

Structural modeling of Vpu from HIV-1 based on solid-state NMR observables

Authors 

Seon Joo AhnGyu Tae LimS NamJinhyuk Lee

Publisher 

Elsevier

Issue Date 

2014

Citation 

Chemical Physics Letters, vol. 599, no. 0, pp. 116-121

Abstract 

Vpu is one of the accessory proteins of HIV-1, and is involved in viral particle release. Viral particle release is enhanced by two proposed functions of Vpu: (i) tetherin interaction and (ii) membrane polarization. Two Vpu functions in viral particle release are still controversial. Here, we investigated the proposed functions by extensive structural modeling of Vpu based on solid-state NMR (Nuclear Magnetic Resonance) observables. We found that Vpu can co-exist in two structural forms: left-handed and right-handed conformation. The co-existence of the two conformations provides a clue to reconcile the controversial issue of its two functions in virus particle release.

ISSN 

0009-2614

Link 

http://dx.doi.org/10.1016/j.cplett.2014.03.033

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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