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Title 

Low-dose radiation suppresses pokemon expression under hypoxic conditions

Authors 

S W KimKweon YuKee Sun ShinK KwonT S HwangO Y Kwon

Publisher 

Verlag der Zeitschrift Fuer Naturforschung

Issue Date 

2014

Citation 

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences, vol. 69c, no. 1, pp. 68-74

Keywords 

HypoxiaLow-dose radiation (LDR)Pokemon

Abstract 

Our previous data demonstrated that CoCl2-induced hypoxia controls endoplasmic reticulum (ER) stress-associated and other intracellular factors. One of them, the transcription factor Pokemon, was differentially regulated by low-dose radiation (LDR). There are limited data regarding how this transcription factor is involved in expression of the unfolded protein response (UPR) under hypoxic conditions. The purpose of this study was to obtain clues on how Pokemon is involved in the UPR. Pokemon was selected as a differentially expressed gene under hypoxic conditions; however, its regulation was clearly repressed by LDR. It was also demonstrated that both expression of ER chaperones and ER stress sensors were affected by hypoxic conditions, and the same results were obtained when cells in which Pokemon was up- or down-regulated were used. The current state of UPR and LDR research associated with the Pokemon pathway offers an important opportunity to understand the oncogenesis, senescence, and differentiation of cells, as well as to facilitate introduction of new therapeutic radiopharmaceuticals.

ISSN 

0939-5075

Link 

http://dx.doi.org/10.5560/ZNC.2013-0035

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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