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Title 

Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging

Authors 

Eun Kyung LimB KangY ChoiE JangS HanK LeeJ S SuhS HaamY M Huh

Publisher 

Institute of Physics

Issue Date 

2014

Citation 

Nanotechnology, vol. 25, no. 24, pp. 245103-245103

Keywords 

gadoliniumhigh sensitivityimaging agentmagnetic resonance image

Abstract 

We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.

ISSN 

0957-4484

Link 

http://dx.doi.org/10.1088/0957-4484/25/24/245103

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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