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Title 

Violapyrones H and I, new cytotoxic compounds isolated from Streptomyces sp. associated with the marine starfish Acanthaster planci

Authors 

H J ShinH S LeeJ S LeeJ ShinM A LeeY J LeeJieun YunJong Soon Kang

Publisher 

MDPI

Issue Date 

2014

Citation 

Marine Drugs, vol. 12, no. 6, pp. 3283-3291

Keywords 

Anti-cancer activityStarfishStreptomyces sp.Violapyronesα-pyrones

Abstract 

Two new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (1-4) exhibited cytotoxicity against 10 human cancer cell lines with GI50 values of 1.10-26.12 μg/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C.

ISSN 

1660-3397

Link 

http://dx.doi.org/10.3390/md12063283

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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