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Title 

One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging

Authors 

A KukrejaEun Kyung LimB KangY ChoiT LeeJ S SuhY M HuhS Haam

Publisher 

American Society for Nanomedicine

Issue Date 

2014

Citation 

International Journal of Nanomedicine, vol. 9, no. 1, pp. 2489-2498

Keywords 

AtherosclerosisDextranMacrophagesMagnetic nanocrystalMagnetic resonance imaging

Abstract 

In this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease.

ISSN 

1178-2013

Link 

http://dx.doi.org/10.2147/IJN.S55525

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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