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Title 

Induction of cytochrome P450 3A1 expression by diallyl disulfide: protective effects against cyclophosphamide-induced embryo-fetal developmental toxicity

Authors 

S H KimI C LeeH S BaekC MoonJ C YooIn Sik ShinJ C Kim

Publisher 

Elsevier

Issue Date 

2014

Citation 

Food and Chemical Toxicology, vol. 69, no. 0, pp. 312-319

Keywords 

CyclophosphamideCytochrome P450 3A1Developmental toxicityDiallyl disulfideOxidative stress

Abstract 

The protective effects of diallyl disulfide (DADS) on cyclophosphamide (CP)-induced developmental toxicity and the possible mechanisms involved in this protection were investigated in rats. In order to study the mechanisms involved in the protection, we examined the effects of DADS on the expression of cytochrome P450 (CYP) 3A1 in the maternal liver and placenta and oxidative stress in the maternal hepatic tissues caused by CP. CP caused severe embryo-fetal developmental toxicity and hepatic oxidative stress. In contrast, DADS treatment significantly attenuated CP-induced developmental toxicity and oxidative damage in the maternal liver. DADS also significantly increased expression of CYP3A1 in the maternal liver and placenta. These results indicate that the protective effects of DADS against CP-induced developmental toxicity may be due to its ability to promote detoxification of CP, primarily by inducing CYP3A1 expression in the maternal liver and placenta, and its potent antioxidant effects.

ISSN 

0278-6915

Link 

http://dx.doi.org/10.1016/j.fct.2014.04.024

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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