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Title 

Antiviral activity of 3,4'-dihydroxyflavone on influenza a virus

Authors 

M K HossainH Y ChoiJae-Seon HwangA A DayemJ H KimY B KimHaryoung PooS G Cho

Publisher 

Microbiological Society of Korea

Issue Date 

2014

Citation 

Journal of Microbiology, vol. 52, no. 6, pp. 521-526

Keywords 

3,4′dihydroxyflavone3-hydroxyl group flavonoidsflavonoidinfluenza virus

Abstract 

Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2′dihydroxyflavone (3,2′DHF) and 3,4′dihydroxyflavone (3,4′DHF), showed potent anti-influenza activity. They inhibited viral neuraminidase activity and viral adsorption onto cells. To confirm the anti-influenza activity of these flavonoids, we used an in vivo mouse model. In mice infected with human influenza, oral administration of 3,4′DHF significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death. Our data suggest that 3-hydroxyl group flavonoids, particularly 3,4′DHF, have potent antiviral activity against human influenza A/PR/8/34 (H1N1) in vitro and in vivo. Further clinical studies are needed to investigate the therapeutic and prophylactic potential of the 3-hydroxyl group flavonoids in treating influenza pandemics.

ISSN 

1225-8873

Link 

http://dx.doi.org/10.1007/s12275-014-4212-z

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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