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Title 

Differential expression pattern of gangliosides during the differentiation of human dental pulp-derived mesenchymal stem cells into dopaminergic neural-like cells

 

인간 치골유래 중간엽 줄기세포에서 도파민 신경세포를 분리하여 갱글리오사이드의 발현 분석

Authors 

S H LeeD H KwakJ S RyuM U LimJi-Su KimSun-Uk KimKyu Tae ChangY K Choo

Publisher 

Zoological Society of Korea

Issue Date 

2014

Citation 

Animal Cells and Systems, vol. 18, no. 3, pp. 210-216

Keywords 

dopaminergic neural differentiationgangliosideshuman dental pulp-derived stem cells

Abstract 

Human dental pulp-derived stem cells (hDPSCs) have been considered as alternative sources of adult stem cells because of their potential to differentiate into multiple cell lineages. Gangliosides, which sialic acid-containing glycosphingolipids are abundantly expressed in the plasma membrane and which play an important role in various processes, such as proliferation and differentiation. This study investigated the possible role of gangliosides in dopaminergic neural differentiation. When hDPSCs were cultured under dopaminergic neural differentiation conditions, the expression of dopaminergic neural cell markers genes such as TH, Pitx-3, Nurr-1, and DAT were detected. Immunofluorescence analysis showed that ganglioside biosynthesis was associated with the dopaminergic neural differentiation of hDPSCs. Specifically, GD3 and GT1b were expressed during dopaminergic neural differentiation. These results suggest that gangliosides may play a role in the dopaminergic neural differentiation process of hDPSCs.

ISSN 

1976-8354

Link 

http://dx.doi.org/10.1080/19768354.2014.909370

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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