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Title 

nc886, a non-coding RNA of anti-proliferative role, is suppressed by CpG DNA methylation in human gastric cancer

Authors 

K S LeeJong Lyul ParkK LeeL E RichardsonB H JohnsonH S LeeJ S LeeS B KimO H KwonK S SongYong Sung KimH AshktorabD T SmootS H JeonSeon-Young KimY S Lee

Publisher 

Impact Journals

Issue Date 

2014

Citation 

Oncotarget, vol. 5, no. 11, pp. 3944-3955

Keywords 

Cell proliferationCpG DNA methylationGastric cancernc886Tumor suppressor

Abstract 

nc886 is a 101 nucleotide long non-coding RNA that has been designated as a precursor microRNA or a vault RNA based upon it sequence. nc886 has also been suggested to be a tumor suppressor, mainly inferred by its expression pattern as well as its genomic location at human chromosome 5q31, a locus for a tumor suppressor gene(s). However, legitimate data based on nc886's correct identity for its functional cellular roles as a tumor suppressor have not been provided yet. Here we have investigated nc886 in gastric cancer where its expression is suppressed due to CpG DNA hypermethylation at its promoter region in a cohort of paired tumor/normal tissues from 88 gastric cancer patients. CpG hypermethylation of nc886 and thus its diminished expression is significantly associated with poor survival in these cancer patients. nc886 inhibits cell proliferation when ectopically expressed in gastric cancer cells. nc886's tumor suppressive role is corroborated by the induction of well-known oncogenes such as FOS, NF-κB, and MYC upon its knockdown. All these activities of nc886 are undoubtedly independent of mature microRNA or vault RNA. Our data indicate that nc886 is a putative tumor suppressor and could potentially be used as a diagnostic marker in gastric cancer.

ISSN 

1949-2553

Link 

http://dx.doi.org/10.18632/oncotarget.2047

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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