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Title 

Therapeutically targeting neuroinflammation and microglia after acute ischemic stroke

Authors 

Youngjeon LeeSang-Rae LeeS S ChoiHyeon-Gu YeoKyu Tae ChangH J Lee

Publisher 

Hindawi Publishing Corporation

Issue Date 

2014

Citation 

BioMed Research International, vol. 2014, no. 0, pp. 297241-297241

Abstract 

Inflammation has a pivotal role in the pathogenesis of ischemic stroke, and recent studies posit that inflammation acts as a double-edged sword, not only detrimentally augmenting secondary injury, but also potentially promoting recovery. An initial event of inflammation in ischemic stroke is the activation of microglia, leading to production of both pro- and anti-inflammatory mediators acting through multiple receptor signaling pathways. In this review, we discuss the role of microglial mediators in acute ischemic stroke and elaborate on preclinical and clinical studies focused on microglia in stroke models. Understanding how microglia can lead to both pro- and anti-inflammatory responses may be essential to implement therapeutic strategies using immunomodulatory interventions in ischemic stroke.

ISSN 

2314-6133

Link 

http://dx.doi.org/10.1155/2014/297241

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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