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Title 

Flavonoids from Lindera glauca Blume as low-density lipoprotein oxidation inhibitors

Authors 

G W HuhJ H ParkJi Hyun KangTae Sook JeongH C KangN I Baek

Publisher 

Taylor & Francis

Issue Date 

2014

Citation 

Natural Product Research, vol. 28, no. 11, pp. 831-834

Keywords 

FlavonoidLDL-oxidationLindera glaucaNMR

Abstract 

In order to identify antioxidant flavonoids from Lindera glauca Blume, we performed phytochemical analysis of L. glauca Blume heartwood and isolated eight flavonoids - lindeglaucol (1), lindeglaucone (2), cilicicone B (3), tamarixetin 3-O-α-L-rhamnoside (4), procyanidin A2 (5), cinnamtannin B1 (6), cinnamtannin D1 (7), and procyanidin A1 (8) - through repeated column chromatography over silica gel (SiO2), octadecyl silica gel (ODS) and Sephadex LH-20. The chemical structures of compounds 1-8 were elucidated from spectroscopic data (NMR, IR and MS). The low-density lipoprotein oxidation inhibitory activities of the isolated compounds were evaluated in vitro by using the thiobarbituric acid reactive substances assay. Compounds 5-8 exhibited high inhibition activity, comparable to the positive control butyl hydroxyl toluene. Compounds 2 and 3 were slightly less active, while 1 and 4 expressed low activity.

ISSN 

1478-6419

Link 

http://dx.doi.org/10.1080/14786419.2013.879583

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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