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Title 

The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice

Authors 

M R LeeC J LimY H LeeJ G ParkS K SonnM N LeeI H JungS J JeongS JeonM LeeK S OhY YangJ B KimH S ChoiW JeongTae Sook JeongWoon Kee YoonHyoung-Chin KimJ H ChoiG T Oh

Publisher 

Nature Publishing Group

Issue Date 

2014

Citation 

Nature Communications, vol. 5, no. 0, pp. 4410-4410

Abstract 

Hyperlipidemia is a well-recognized risk factor for atherosclerosis and can be regulated by adipokines. Expression of the adipokine resistin-like molecule alpha (Retnla) is regulated by food intake; whether Retnla has a role in the pathogenesis of hyperlipidemia and atherosclerosis is unknown. Here we report that Retnla has a cholesterol-lowering effect and protects against atherosclerosis in low-density lipoprotein receptor-deficient mice. On a high-fat diet, Retnla deficiency promotes hypercholesterolaemia and atherosclerosis, whereas Retnla overexpression reverses these effects and improves the serum lipoprotein profile, with decreased cholesterol in the very low-density lipoprotein fraction concomitant with reduced serum apolipoprotein B levels. We show that Retnla upregulates cholesterol-7-α -hydroxylase, a key hepatic enzyme in the cholesterol catabolic pathway, through induction of its transcriptional activator liver receptor homologue-1, leading to increased excretion of cholesterol in the form of bile acids. These findings define Retnla as a novel therapeutic target for treating hypercholesterolaemia and atherosclerosis.

ISSN 

2041-1723

Link 

http://dx.doi.org/10.1038/ncomms5410

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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