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Title 

Genomic encyclopedia of bacteria and archaea: sequencing a myriad of type strains

Authors 

N C KyrpidesP HugenholtzJ A EisenT WoykeM GokerC T ParkerR AmannB J BeckP S G ChainJ ChunR R ColwellA DanchinP DawyndtT DedeurwaerdereE F DeLongJ C DetterP D VosT J DonohueX Z DongD S EhrlichC FraserR GibbsJ GilbertJung-Sook LeeH P Klenk

Publisher 

Public Library of Science

Issue Date 

2014

Citation 

Plos Biology, vol. 12, no. 8, pp. 1001920-1001920

Abstract 

Microbes hold the key to life. They hold the secrets to our past (as the descendants of the earliest forms of life) and the prospects for our future (as we mine their genes for solutions to some of the planet's most pressing problems, from global warming to antibiotic resistance). However, the piecemeal approach that has defined efforts to study microbial genetic diversity for over 20 years and in over 30,000 genome projects risks squandering that promise. These efforts have covered less than 20% of the diversity of the cultured archaeal and bacterial species, which represent just 15% of the overall known prokaryotic diversity. Here we call for the funding of a systematic effort to produce a comprehensive genomic catalog of all cultured Bacteria and Archaea by sequencing, where available, the type strain of each species with a validly published name (currently∼11,000). This effort will provide an unprecedented level of coverage of our planet's genetic diversity, allow for the large-scale discovery of novel genes and functions, and lead to an improved understanding of microbial evolution and function in the environment.

ISSN 

1544-9173

Link 

http://dx.doi.org/10.1371/journal.pbio.1001920

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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