상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

The lactone form of stachybotrydial: a new inhibitor of dihydrofolate reductase from Stachybotrys sp. FN298

Authors 

Yun Ju KwonMi-Jin SohnHyun Ju KimWon Gon Kim

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2014

Citation 

Biological & Pharmaceutical Bulletin, vol. 37, no. 8, pp. 1406-1410

Keywords 

Dihydrofolate reductaseStachybotrydialStachybotrysStaphylococcus aureus

Abstract 

Dihydrofolate reductase (DHFR) has been confirmed to be a novel target for antibacterial drug development. In this study, we determined that a fungal metabolite from Stachybotrys sp. FN298 can inhibit the DHFR of Staphylococcus aureus. Its structure was identified as a lactone form of stachybotrydial using mass spectrometry and nuclear magnetic resonance analysis. This compound inhibited S. aureus DHFR with a half-maximal inhibitory concentration of 41 μM. It also prevented the growth of S. aureus and methicillinresistant S. aureus (MRSA) with a minimum inhibitory concentration of 32 μg?mL-1. To our knowledge, this is the first description of a DHFR inhibitor of microbial origin. The inhibitory function of the lactone form of stachybotrydial highlights its potential for development into a new broad-spectrum antibacterial agent and as an agent against MRSA.

ISSN 

0918-6158

Link 

http://doi.org/10.1248/bpb.b14-00108

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


Files in This Item: SizeFormat
12480.pdf379KbAdobe PDF
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)