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Title 

Siegesbeckia glabrescens attenuates allergic airway inflammation in LPS-stimulated RAW 264.7 cells and OVA induced asthma murine model

 

시게스베키아의 항염증 및 항천식 효과

Authors 

Chan Mi JeonIn Sik ShinNa Rae ShinJu Mi HongOk-Kyoung KwonHui Seong KimSei-Ryang OhP K MyungKyung Seop Ahn

Publisher 

Elsevier

Issue Date 

2014

Citation 

International Immunopharmacology, vol. 22, no. 2, pp. 414-419

Keywords 

AsthmaCytokineInducible nitric oxide synthaseInflammationSiegesbeckia glabrescens

Abstract 

Siegesbeckia glabrescens (SG) is a plant growing in Korea that is used as a traditional medicine for various inflammatory diseases. In this study, we investigated the protective effects of SG extract on allergic asthma in an ovalbumin (OVA)-induced asthma murine model and lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Female BALB/c mice were sensitized by intraperitoneal injection of OVA on days 0 and 14 and then challenged with OVA from days 21 to 23. SG (30 mg/kg) was administered by oral gavage 1 h before the OVA challenge. LPS-stimulated RAW264.7 cells were evaluated to determine their levels of nitric oxide (NO). The SG significantly reduced the number of inflammatory cells in bronchoalveolar lavage (BAL) fluid and also reduced IL-4, IL-5, IL-13, eotaxin and immunoglobulin E in OVA-sensitized/challenged mice. SG also effectively reduced airway inflammation and mucus overproduction in lung tissue in addition to decreasing the expression of iNOS and COX-2. In LPS-stimulated RAW264.7 cells, SG treatment significantly reduced the levels of NO. These findings indicate that SG effectively suppressed inflammatory responses, and its effects appear to be related to reduction in iNOS and COX-2 expression. Therefore, we suggest that SG may have potential use as a therapeutic agent for inflammatory diseases such as allergic asthma.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2014.07.013

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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