상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Subcellular neural probes from single-crystal gold nanowires

Authors 

M KangS JungH ZhangTaejoon KangH KangY YooJ P HongJ P AhnJ KwakD JeonN A KotovB Kim

Publisher 

American Chemical Society

Issue Date 

2014

Citation 

ACS Nano, vol. 8, no. 8, pp. 8182-8189

Keywords 

BRAIN initiativebrain-machine interfaceelectrode miniaturizationepilepsygold nanowirelong-term neural recordingsnanoelectrodeneural implantsneurodegenerative diseaseneuroprostheticsparalysissingle-neuron detectionsubcellular-sized implants

Abstract 

Size reduction of neural electrodes is essential for improving the functionality of neuroprosthetic devices, developing potent therapies for neurological and neurodegenerative diseases, and long-term brain-computer interfaces. Typical neural electrodes are micromanufactured devices with dimensions ranging from tens to hundreds of micrometers. Their further miniaturization is necessary to reduce local tissue damage and chronic immunological reactions of the brain. Here we report the neural electrode with subcellular dimensions based on single-crystalline gold nanowires (NWs) with a diameter of ∼100 nm. Unique mechanical and electrical properties of defect-free gold NWs enabled their implantation and recording of single neuron-activities in a live mouse brain despite a ∼50× reduction of the size compared to the closest analogues. Reduction of electrode dimensions enabled recording of neural activity with improved spatial resolution and differentiation of brain activity in response to different social situations for mice. The successful localization of the epileptic seizure center was also achieved using a multielectrode probe as a demonstration of the diagnostics potential of NW electrodes. This study demonstrated the realism of single-neuron recording using subcellular-sized electrodes that may be considered a pivotal point for use in diverse studies of chronic brain diseases.

ISSN 

1936-0851

Link 

http://dx.doi.org/10.1021/nn5024522

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)