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Title 

MicroRNA-29a suppresses the growth, migration, and invasion of lung adenocarcinoma cells by targeting carcinoembryonic antigen-related cell adhesion molecule 6

Authors 

H S HanS M SonJi Eun YunY N JoO J Lee

Publisher 

Elsevier

Issue Date 

2014

Citation 

FEBS Letters, vol. 588, no. 20, pp. 3744-3750

Keywords 

adhesion molecule 6Carcinoembryonic antigen-related cellLung adenocarcinomaMicroRNA 29a

Abstract 

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an important regulator of cell adhesion, invasion, and metastasis. The aim of this study was to evaluate the functional roles of CEACAM6 in lung adenocarcinoma and to identify miRNAs that inhibit the growth, migration, and invasion of lung adenocarcinoma cells by targeting CEACAM6. CEACAM6 expression is associated with poor prognosis of patients with lung adenocarcinoma, and CEACAM6 has important functional roles in controlling the growth, migration, and invasion of lung adenocarcinoma cells in vitro and in vivo. Furthermore, miR-29a can suppress the growth, migration, and invasion of lung adenocarcinoma cells by targeting CEACAM6. Therefore, miR-29a/CEACAM6 axis represents a potential therapeutic target for treatment of lung adenocarcinoma.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/j.febslet.2014.08.023

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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