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Title 

Human ChlR1 stimulates endonuclease activity of hFen1 independently of ATPase activity

 

ATPase 활성과 무관하게 hFen1의 endonuclase 활성을 증진시키는 인간 ChlR1

Authors 

D H KimJeong Hoon KimByoung Chul ParkD H LeeS ChoSung Goo Park

Publisher 

The Korean Chemical Society

Issue Date 

2014

Citation 

Bulletin of the Korean Chemical Society, vol. 35, no. 10, pp. 3005-3008

Keywords 

ChlR1Dna2Fen1Okazaki fragment processing

Abstract 

Human ChlR1 protein (hChlR1), a member of the cohesion establishment factor family, plays an important role in the segregation of sister chromatids for maintenance of genome integrity. We previously reported that hChlR1 interacts with hFen1 and stimulates its nuclease activity on the flap-structured DNA substrate covered with RPA. To elucidate the relationship between hChlR1 and Okazaki fragment processing, the effect of hChlR1 on in vitro nuclease activities of hFen1 and hDna2 was examined. Independent of ATPase activity, hChlR1 stimulated endonuclease activity of hFen1 but not that of hDna2. Our findings suggest that the acceleration of Okazaki fragment processing near cohesions may aid in reducing the size of the replication machinery, thereby facilitating its entry through the cohesin ring

ISSN 

0253-2964

Link 

http://dx.doi.org/10.5012/bkcs.2014.35.10.3005

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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