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Title 

Salvia plebeia suppresses atopic dermatitis-like skin lesions

 

곰보배추의 아토피성 피부병변 저해 활성

Authors 

J K ChoiHyun-Mee OhS LeeT K KwonT Y ShinMun Chual RhoS H Kim

Publisher 

World Scientific Publishing

Issue Date 

2014

Citation 

American Journal of Chinese Medicine, vol. 42, no. 4, pp. 967-985

Keywords 

Atopic DermatitisKeratinocytesSalvia plebeia

Abstract 

Salvia plebeia R. Br. (Lamiaceae) has been used for folk medicines in Asian countries, including Korea and China, to treat skin inflammatory diseases and asthma. In this study, we investigated the effects of S. plebeia extract (SPE) on atopic dermatitis (AD)-like skin lesions and defined underlying mechanisms of action. We established an AD model in BALB/c mice by repeated local exposure of house dust mite extract (Dermatophagoides farinae extract, DFE) and 2,4-dinitrochlorobenzene (DNCB) to the ears. Repeated alternative treatment of DFE/DNCB caused AD-like skin lesions. The oral administration of SPE decreased AD symptoms based on ear thickness and histopathological analysis, in addition to serum IgE and IgG2a levels. SPE suppressed mast cell infiltration into the ear and serum histamine level. SPE inhibited Th1/Th2/Th17 phenotype CD4 + T lymphocytes expansion in the lymph node and the expression of Th1/Th2/Th17 cytokines in the ear tissue. To define the underlying mechanisms of action, the tumor necrosis factor (TNF)-α and interferon (IFN)-γ activated human keratinocytes (HaCaT) model was used. SPE significantly suppressed the expression of cytokines and chemokines through the down-regulation of mitogen-activated protein kinases, nuclear factor-κB, and STAT1 in HaCaT cells. Taken together, our results suggest that SPE might be a candidate for the treatment of AD.

ISSN 

0192-415X

Link 

http://dx.doi.org/10.1142/S0192415X1450061X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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