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Title 

Inhibition of the calcineurin pathway by two tannins, chebulagic acid and chebulanin, isolated from Harrisonia abyssinica Oliv.

 

Harrisonia abyssinica Oliv.로부터 분리한 2종류의 탄닌 화합물, chebulagic와 chebulanin에 의한 calcineurin 경로의 저해

Authors 

Won Jeong LeeJae Sun MoonS I KimYoung Tae KimO NashY S BahnSung Uk Kim

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2014

Citation 

Journal of Microbiology and Biotechnology, vol. 24, no. 10, pp. 1377-1381

Abstract 

In order to discover and develop novel signaling inhibitors from plants, a screening system was established targeting the two-component system of Cryptococcus neoformans by using the wild type and a calcineurin mutant of C. neoformans, based on the counter-regulatory action of high-osmolarity glycerol (Hog1) mitogen-activated protein kinase and the calcineurin pathways in C. neoformans. Among 10,000 plant extracts, that from Harrisonia abyssinica Oliv. exhibited the most potent inhibitory activity against C. neoformans var. grubii H99 with fludioxonil. Bioassay-guided fractionation was used to isolate two bioactive compounds from H. abyssinica, and these compounds were identified as chebulagic acid and chebulanin using spectroscopic methods. These compounds specifically inhibited the calcineurin pathway in C. neoformans. Moreover, they exhibited potent antifungal activities against various human pathogenic fungi with minimum inhibitory concentrations ranging from 0.25 to over 64 ?g/ml.

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.1405.05030

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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