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Title 

Anti-inflammatory effect of mangostenone F in lipopolysaccharide-stimulated RAW264.7 macrophages by suppressing NF-κB and MAPK activation

Authors 

B O ChoHyung Won RyuY SoC W LeeC H JinH S YookY W JeongJ C ParkI Y Jeong

Publisher 

Korean Society of Applied Pharmacology

Issue Date 

2014

Citation 

Biomolecules & Therapeutics, vol. 22, no. 4, pp. 288-294

Keywords 

iNOSMangostenone FMAPKNF-κBNO

Abstract 

Mangostenone F (MF) is a natural xanthone isolated from Garcinia mangostana. However, little is known about the biological activities of MF. This study was designed to investigate the anti-inflammatory effect and underlying molecular mechanisms of MF in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. MF dose-dependently inhibited the production of NO, iNOS, and pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) in LPS-stimulated RAW264.7 macrophages. Moreover, MF decreased the NF-κB luciferase activity and NF-κB DNA binding capacity in LPS-stimulated RAW264.7 macrophages. Furthermore, MF suppressed the NF-κB activation by inhibiting the degradation of IκBα and nuclear translocation of p65 subunit of NF-κB. In addition, MF attenuated the AP-1 luciferase activity and phosphorylation of ERK, JNK, and p38 MAP kinases. Taken together, these results suggest that the anti-inflammatory effect of MF is associated with the suppression of NO production and iNOS expression through the down-regulation of NF-κB activation and MAPK signaling pathway in LPS-stimulated RAW264.7 macrophages.

ISSN 

1976-9148

Link 

http://dx.doi.org/10.4062/biomolther.2014.052

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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