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Title 

Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells

Authors 

S T NamJung Hwan HwangD H KimM J ParkI H LeeH J NamJ K KangS K KimJ S HwangH K ChungM ShongChul Ho LeeH Kim

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2014

Citation 

BMB Reports, vol. 47, no. 9, pp. 494-499

Keywords 

Barrier dysfunction of epithelial cellsChromosome condensationClaudin-1Gut epithelial cell tight junctionGut inflammationHistone acetylation/deacetylationNQO1 knockout miceOccludinTranscription

Abstract 

NADH:quinone oxidoreductase 1 (NQO1) is known to be involved in the regulation of energy synthesis and metabolism, and the functional studies of NQO1 have largely focused on metabolic disorders. Here, we show for the first time that compared to NQO1-WT mice, NQO1-KO mice exhibited a marked increase of permeability and spontaneous inflammation in the gut. In the DSS-induced colitis model, NQO1-KO mice showed more severe inflammatory responses than NQO1-WT mice. Interestingly, the transcript levels of claudin and occludin, the major tight junction molecules of gut epithelial cells, were significantly decreased in NQO1-KO mice. The colons of NQO1-KO mice also showed high levels of reactive oxygen species (ROS) and histone deacetylase (HDAC) activity, which are known to affect transcriptional regulation. Taken together, these novel findings indicate that NQO1 contributes to the barrier function of gut epithelial cells by regulating the transcription of tight junction molecules.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2014.47.9.196

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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