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Title 

Characterization of an H4N2 influenza virus from Quails with a multibasic motif in the hemagglutinin cleavage site

Authors 

S S WongSun Woo YoonM ZaninC OshanskyH ZaraketS SonnbergA RubrumP SeilerA FergusonS KraussC CardonaR J WebbyB Crossley

Publisher 

Elsevier

Issue Date 

2014

Citation 

Virology, vol. 468, no. 0, pp. 72-80

Keywords 

H4N2Low pathogenic avian influenzaMultibasic cleavage siteOutbreakQuail

Abstract 

The cleavage motif in the hemagglutinin (HA) protein of highly pathogenic H5 and H7 subtypes of avian influenza viruses is characterized by a peptide insertion or a multibasic cleavage site (MBCS). Here, we isolated an H4N2 virus from quails (Quail/CA12) with two additional arginines in the HA cleavage site, PEK. RRTR/G, forming an MBCS-like motif. Quail/CA12 is a reassortant virus with the HA and neuraminidase (NA) gene most similar to a duck-isolated H4N2 virus, PD/CA06 with a monobasic HA cleavage site. Quail/CA12 required exogenous trypsin for efficient growth in culture and caused no clinical illness in infected chickens. Quail/CA12 had high binding preference for α2,6-linked sialic acids and showed higher replication and transmission ability in chickens and quails than PD/CA06. Although the H4N2 virus remained low pathogenic, these data suggests that the acquisition of MBCS in the field is not restricted to H5 or H7 subtypes.

ISSN 

0042-6822

Link 

http://dx.doi.org/10.1016/j.virol.2014.07.048

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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