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Title 

Genome-wide profiling of the microRNA-mRNA regulatory network in skeletal muscle with aging

 

유전체 분석을 통한 노화에 따른 근육의 microRNA-mRNA 네트워크 규명

Authors 

Ji Young KimYoung Kyu ParkKwang-Pyo LeeSeung Min LeeTae-Wook KangHee Jin KimSo Hee DhoSeon-Young KimKi Sun Kwon

Publisher 

Impact Journals

Issue Date 

2014

Citation 

Aging, vol. 6, no. 7, pp. 524-544

Keywords 

AgingImprinted Dlk1-Dio3MicroRNA clusterMicroRNA profilingNovel microRNASkeletal muscle

Abstract 

Skeletal muscle degenerates progressively, losing mass (sarcopenia) over time, which leads to reduced physical ability and often results in secondary diseases such as diabetes and obesity. The regulation of gene expression by microRNAs is a key event in muscle development and disease. To understand genome-wide changes in microRNAs and mRNAs during muscle aging, we sequenced microRNAs and mRNAs from mouse gastrocnemius muscles at two different ages (6 and 24 months). Thirty-four microRNAs (15 up-regulated and 19 down-regulated) were differentially expressed with age, including the microRNAs miR-206 and -434, which were differentially expressed in aged muscle in previous studies. Interestingly, eight microRNAs in a microRNA cluster at the imprinted Dlk1-Dio3 locus on chromosome 12 were coordinately down-regulated. In addition, sixteen novel microRNAs were identified. Integrative analysis of microRNA and mRNA expression revealed that microRNAs may contribute to muscle aging through the positive regulation of transcription, metabolic processes, and kinase activity. Many of the age-related microRNAs have been implicated in human muscular diseases. We suggest that genome-wide microRNA profiling will expand our knowledge of microRNA function in the muscle aging process.

ISSN 

1945-4589

Link 

http://dx.doi.org/10.18632/aging.100677

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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