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Title 

Tussilago farfara L. augments TRAIL-induced apoptosis through MKK7/JNK activation by inhibition of MKK7-TIPRL in human hepatocellular carcinoma cells

 

간암세포주 Tussilago farfara L. 추출물 MKK7-TIPRL의 결합저해와 MKK7/JNK activation의 TRAIL유도 세포사멸

Authors 

Hyo Jung LeeHyun Soo ChoSoo Young JunJeong Ju LeeJi Yong YoonJae Hye LeeHyuk-Hwan SongSangho ChoiSoo Yong KimV SalouraC G ParkNam-Soon Kim

Publisher 

Spandidos Publications

Issue Date 

2014

Citation 

Oncology Reports, vol. 32, no. 3, pp. 1117-1123

Keywords 

ApoptosisHCCMKK7TIPRLTRAIL resistanceTussilago farfara L.

Abstract 

Induction of apoptosis through activation of the TRAIL pathway is considered to be a promising anticancer strategy due to its ability to selectively induce apoptosis in cancer cells. However, the ability of cancer cells to acquire TRAIL resistance has limited the clinical translation of this approach. We previously reported that the TOR signaling pathway regulator-like (TIPRL) protein contributes to the resistance to TRAIL-induced apoptosis by inhibiting the MKK7-c-Jun N-terminal kinase (JNK) pathway via MKK7?TIPRL interaction. In the present study, we identified Tussilago farfara L. (TF) as a novel TRAIL sensitizer among 500 natural products using an ELISA system that specifically detects the MKK7-TIPRL interaction, and we validated candidates by GST-pull down assay. Co-treatment of Huh7 cells with TF and TRAIL induced apoptosis via inhibition of the MKK7-TIPRL interaction and an increase in MKK7/JNK phosphorylation. This is the first report to describe TF as a novel TRAIL sensitizer, unveiling a potentially novel therapeutic strategy in cancer therapy

ISSN 

1021-335X

Link 

http://dx.doi.org/10.3892/or.2014.3279

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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