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Title 

Cytotoxic sesterterpenoids isolated from the marine sponge Scalarispongia sp.

Authors 

Y J LeeJ W LeeD G LeeH S LeeJong Soon KangJi Eun Yun

Publisher 

MDPI AG

Issue Date 

2014

Citation 

International Journal of Molecular Sciences, vol. 15, no. 11, pp. 20045-20053

Keywords 

CytotoxicityScalaraneScalarispongiaSesterterpenoidSponge

Abstract 

Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI50 values down to 5.2 μM) against six human cancer cell lines.

ISSN 

1422-0067

Link 

http://dx.doi.org/10.3390/ijms151120045

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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