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Title 

Pterocarpan-enriched soy leaf extract ameliorates insulin sensitivity and pancreatic β-cell proliferation in type 2 diabetic mice

 

테로카판 고함유 콩잎 추출물의 제2형 당뇨모델 마우스에서 인슐린 민감성과 췌장 베타세포 증식을 개선하는 효능

Authors 

Un Hee KimJeong Hyun YoonHua LiJi Hyun KangHyeon Seon JiK H ParkD H ShinHo Yong ParkTae Sook Jeong

Publisher 

MDPI

Issue Date 

2014

Citation 

Molecules, vol. 19, no. 0, pp. 18493-18510

Keywords 

Glycine maxInsulin sensitivityPancreasPterocarpansType 2 diabetes

Abstract 

In Korea, soy (Glycine max (L.) Merr.) leaves are eaten as a seasonal vegetable or pickled in soy sauce. Ethyl acetate extracts of soy leaves (EASL) are enriched in pterocarpans and have potent α-glucosidase inhibitory activity. This study investigated the molecular mechanisms underlying the anti-diabetic effect of EASL in C57BL/6J mice with high-fat diet (HFD)-induced type 2 diabetes. Mice were randomly divided into normal diet (ND), HFD (60 kcal% fat diet), EASL (HFD with 0.56% (wt/wt) EASL), and Pinitol (HFD with 0.15% (wt/wt) pinitol) groups. Weight gain and abdominal fat accumulation were significantly suppressed by EASL. Levels of plasma glucose, HbA1c, and insulin in the EASL group were significantly lower than those of the HFD group, and the pancreatic islet of the EASL group had greater size than those of the HFD group. EASL group up-regulated neurogenin 3 (Ngn3), paired box 4 (Pax4), and v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), which are markers of pancreatic cell development, as well as insulin receptor substrate 1 (IRS1), IRS2, and glucose transporter 4 (GLUT4), which are related to insulin sensitivity. Furthermore, EASL suppressed genes involved in hepatic gluconeogenesis and steatosis. These results suggest that EASL improves plasma glucose and insulin levels in mice with HDF-induced type 2 diabetes by regulating β-cell proliferation and insulin sensitivity.

ISSN 

1420-3049

Link 

http://dx.doi.org/10.3390/molecules191118493

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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