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Title 

Nitric oxide inhibitory constituents from fruits of Opuntia humifusa

Authors 

Y J KangH Y KimChul LeeS Y Park

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2014

Citation 

Natural Products Sciences, vol. 20, no. 3, pp. 211-215

Keywords 

Isorhamnetin derivativesNitric oxideOpuntia humifusaRaw264.7 cells

Abstract 

Opuntia humifusa, also called as Cheonnyuncho, is a cactus widely cultivated in southern regions of Korea. It has been known to have diverse biological activities, but most of the studies were performed with the MeOH extracts or solvent-partitioned fractions. Furthermore, the efforts to identify the responsible compounds for the biological activities are very limited. In this study, we tested the inhibitory effect of extracts and solventpartitioned fractions of O. humifusa against LPS-induced nitric oxide (NO) production in Raw264.7 cells. The butanol fractions of O. humifusa efficiently inhibited the production of NO in Raw264.7 cells, but it was not due to the reduction of cell viability. Bioassay-guided isolation of butanol fractions of O. humifusa allowed the isolation of three flavonoids isorhamnetin 3-O-β-D-galactosyl-4'-O-β-D-glucoside (1), isorhamnetin 3,4'-di-O-β-Dglucoside (2) and isorhamnetin 3-O-β-D-(6-O-α-L-rhamnosyl)glucoside (3), and one lignan syringaresinol O-β-Dglucopyranoside (4). Among them, isorhamnetin 3-O-β-D-galactosyl-4'-O-β-D-glucoside (1) and isorhamnetin 3,4'-di-O-β-D-glucoside (2) exhibited the moderate inhibitory effects against LPS-induced NO production. This is the first time to report anti-inflammatory effects of these compounds.

ISSN 

1226-3907

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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