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Title 

Structural insights into the transcription-independent apoptotic pathway of p53

 

p53 의 전사 독립적인 세포사멸 경로에 관한 구조적 이해

Authors 

Seung-Wook Chi

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2014

Citation 

BMB Reports, vol. 47, no. 3, pp. 167-172

Keywords 

Anticancer therapyApoptosisBcl-2 family proteinsp53Structure

Abstract 

Reactivating the p53 pathway in tumors is an important strategy for anticancer therapy. In response to diverse cellular stresses, the tumor suppressor p53 mediates apoptosis in a transcriptionindependent and transcription-dependent manner. Although extensive studies have focused on the transcription-dependent apoptotic pathway of p53, the transcription-independent apoptotic pathway of p53 has only recently been discovered. Molecular interactions between p53 and Bcl-2 family proteins in the mitochondria play an essential role in the transcriptionindependent apoptosis of p53. This review describes the structural basis for the transcription-independent apoptotic pathway of p53 and discusses its potential application to anticancer therapy.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2014.47.3.261

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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