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Title 

Identification of hyperacute ischemic stroke with a more homogenous nature

Authors 

K S YiH J LeeSang-Rae LeeYoung Jeon LeeS Y LeeC LeeS H Cha

Publisher 

De Gruyter Open

Issue Date 

2014

Citation 

Translational Neuroscience, vol. 5, no. 2, pp. 123-130

Keywords 

Acute strokeAnimal modelDiffusion weighted imagingFocal cerebral ischemiaMagnetic resonance imagingRat

Abstract 

Previous reports revealed that middle cerebral artery occlusion (MCAO) models in rats were very diverse in nature, and experimental stroke of a more homogenous nature had not been previously documented. This paper aims to present our novel observations of experimental stroke in rats with similar MRI characteristics after MCAO. Immediately after MCAO, 19 rats were placed into a 4.7 T MRI scanner, and diffusion weighted imaging (DWI) of axial and coronal planes was repeated every 10 minutes up to post-occlusion 115 minutes. Apparent diffusion coefficient (ADC) values of the ischemic lesions were calculated and compared to those of the unaffected contra-lateral hemispheres. Successful MCAO was defined when the whole left MCA territory showed ADC abnormality on DWI. Percentage of hemispheric lesion volume (% HLV), relative ADC value (rADC), and relative DWI signal intensity (rDWI) were serially evaluated for quantitative analysis of ADC-derived lesion characteristics. Successful MCA territorial infarction was induced in nine rats (9/19, 47.4%). In quantitative analysis of ADC-derived lesion characteristics, lesion volumes of seven rats (group 1) were very similar, but larger than those of the other two rats (group 2): % HLV of initial MRI = 45.4 ± 2.5 / 19.1 ± 6.6. rADCs and rDWIs of group 1 showed similar patterns of temporal change, which was different from those of group 2. Using prospective diffusion MRI after MCAO in rats, we identified territorial hyperacute ischemic lesions with similar MRI characteristics. This observation would contribute to the establishment of more homogenous rodent models for ischemic stroke translational research.

ISSN 

2081-3856

Link 

http://dx.doi.org/10.2478/s13380-014-0215-9

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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