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Title 

Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion

Authors 

M J JangYe Sol KimE Y BaeT S OhH J ChoiJ H LeeHyun-Mee OhS W Lee

Publisher 

MDPI

Issue Date 

2014

Citation 

Molecules, vol. 19, no. 12, pp. 20340-20349

Keywords 

Anti-inflammatory agentsBupleurum falcatum lCell adhesion moleculesSaikosaponinSelectinTriterpenoid saponin

Abstract 

Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D ( 3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC50 values of 1.8, 3.0 and 4.3 μM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion. From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation.

ISSN 

1420-3049

Link 

http://dx.doi.org/10.3390/molecules191220340

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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