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Title 

Anti-inflammatory action of γ-irradiated genistein in murine peritoneal macrophage

Authors 

N Y SungE B ByunD S SongYeung Bae JinJ N ParkJ K KimJ H ParkB S SongS H ParkJ W LeeJ H Kim

Publisher 

Elsevier

Issue Date 

2014

Citation 

Radiation Physics and Chemistry, vol. 105, no. 0, pp. 17-21

Keywords 

Anti-inflammatory activityCytokineCytotoxicityGamma irradiationGenistein

Abstract 

This present study was to examine the cytotoxicity and anti-inflammatory activity of gamma (γ)-irradiated genistein in murine peritoneal macrophage. Inflammation to macrophage was induced by adding the lipopolysaccharide (LPS). γ-Irradiated genistein significantly decreased the cytotoxicity to murine peritoneal macrophage in dose ranges from 5 to 10. μM than that of non-irradiated genistein. Anti-inflammatory activity within the doses less than 2. μM showed that γ-irradiated genistein treatment remarkably reduced the lipopolysaccharide-induced inflammation by decreasing the nitric oxide (NO) and cytokines (TNF-α, IL-6) production. In a structural analysis through the high pressure liquid chromatography (HPLC), γ-irradiated genistein showed a new peak production distinguished from main peak of genistein (non-irradiated). Therefore, increase of anti-inflammatory activity may closely mediate with structural changes induced by γ irradiation exposure. Based on the above result, γ-irradiation could be an effective tool for reduction of toxicity and increase of physiological activity of biomolecules.

ISSN 

0969-806X

Link 

http://dx.doi.org/10.1016/j.radphyschem.2014.05.029

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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