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Title 

Meta-review of protein network regulating obesity between validated obesity candidate genes in the white adipose tissue of high-fat diet-induced obese C57BL/6J mice

Authors 

E KimE J KimS W SepCheol-Goo HurR A McGregorM S Choi

Publisher 

Taylor & Francis

Issue Date 

2014

Citation 

Critical Reviews in Food Science and Nutrition, vol. 54, no. 7, pp. 910-923

Keywords 

adipose tissueC57BL/6J mousehigh-fatnutrigenomicsObesity

Abstract 

Worldwide obesity and related comorbidities are increasing, but identifying new therapeutic targets remains a challenge. A plethora of microarray studies in diet-induced obesity models has provided large datasets of obesity associated genes. In this review, we describe an approach to examine the underlying molecular network regulating obesity, and we discuss interactions between obesity candidate genes. We conducted network analysis on functional protein-protein interactions associated with 25 obesity candidate genes identified in a literature-driven approach based on published microarray studies of diet-induced obesity. The obesity candidate genes were closely associated with lipid metabolism and inflammation. Peroxisome proliferator activated receptor gamma (Pparg) appeared to be a core obesity gene, and obesity candidate genes were highly interconnected, suggesting a coordinately regulated molecular network in adipose tissue. In conclusion, the current network analysis approach may help elucidate the underlying molecular network regulating obesity and identify anti-obesity targets for therapeutic intervention.

ISSN 

1040-8398

Link 

http://dx.doi.org/10.1080/10408398.2011.619283

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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