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Title 

Lipid-soluble ginseng extract inhibits invasion and metastasis of B16F10 melanoma cells

Authors 

Ji Eun YunBo Geun KimJong Soon KangS K ParkK LeeD H HyunH M KimM J InD C Kim

Publisher 

Mary Ann Liebert

Issue Date 

2015

Citation 

Journal of Medicinal Food, vol. 18, no. 1, pp. 102-108

Keywords 

cancer invasionlipid-soluble ginseng extractlung metastasismatrix metalloprotease-2

Abstract 

This study was performed to elucidate the effect of a lipid-soluble ginseng extract (LSGE) on cancer invasion and metastasis. The LSGE, even at noncytotoxic concentrations, potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner. In the presence of 3 μg/mL of LSGE, the invasion and migration of B16F10 cells were significantly inhibited by 98.1% and 71.4%, respectively. Furthermore, the LSGE decreased mRNA and protein levels of matrix metalloproteinase (MMP)-2 in B16F10 cells, leading to a decrease in MMP-2 activity. After B16F10 cells were intravenously injected in the tail vein of C57BL/6 mice, 1000mg/kg/day of LSGE was orally administered for 13 days, after which lung metastasis of cancer cells was inhibited by 59.3%. These findings indicate that LSGE inhibits cancer cell invasion and migration in vitro and lung metastasis of melanoma cells in vivo by inhibiting MMP-2 expression.

ISSN 

1096-620X

Link 

http://dx.doi.org/10.1089/jmf.2013.3138

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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