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Title 

Two new lignans from Saururus chinensis and their DGAT inhibitory activity

Authors 

N LiZ D TuoS Z QiS S XingHyun Sun LeeJ G ChenL Cui

Publisher 

Elsevier

Issue Date 

2015

Citation 

Fitoterapia, vol. 101, no. 0, pp. 46-50

Keywords 

DGATLignanSaururaceaeSaururus chinensis

Abstract 

Two new lignans were isolated from Saururus chinensis, along with eight known compounds. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds 2, 3, 5 and 7 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values ranging from 44.3 ± 1.5 to 87.5 ± 1.3 μM.

ISSN 

0367-326X

Link 

http://dx.doi.org/10.1016/j.fitote.2014.12.011

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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